Journal: Frontiers in Neural Circuits

Article Title: Rapid and cumulative adult plasticity in the mouse visual cortex

doi: 10.3389/fncir.2025.1537305

Figure Lengend Snippet: NMDA receptor-dependent FVP (A) VEPs in NR2A knockout mice on days 1 and 6 (contralateral eye stimulation). (B) Absence of changes in VEP peaks (day 1 vs. day 6) in NR2A knockout mice after visual stimulation ( N = 6 mice, 12 recording sites, 24 recordings of contralateral or ipsilateral eye stimulation). Mann–Whitney test, N1: p = 0.5775; P1: p = 0.5844; N2: p = 0.4964. (C) VEPs of wild-type mice injected with MK801 intraperitoneally (0.5 mg/kg body weight) (day 1 vs. day 6, contralateral eye stimulation) 30 min before the start of visual stimulation. (D) Absence of FVP (day 1 vs. day 6) in MK801 treated wild type mice after visual stimulation. VEP peak N2 amplitudes ( N = 6 mice, 12 recording sites, 24 recordings of contralateral or ipsilateral eye stimulation). Mann–Whitney test, N1: p = 0.1305; P1: p = 0.4552, N2: p = 0.1060. (E) Impaired rapid potentiation in NR2A KO mice. Visual response (area under waveform) during the initial stimulation (0–10 pulses) vs. late stimulation (190–200 pulses) on day 1. Paired t -test, p = 0.924, 6 mice, t = 0.1002, df = 5.

Article Snippet: The NMDA receptor antagonist MK801 (FUJIFILM Wako Pure Chemical Corporation, Osaka, Japan) was dissolved in saline (0.1 mg/mL) and administered intraperitoneally (0.5 mg/kg) 15 min before daily recording sessions for 6 consecutive days.

Techniques: Knock-Out, MANN-WHITNEY, Injection